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Cosmetic ResearchAHK-Cu
Copper-binding tripeptide studied for hair follicle biology, dermal papilla cell signalling, and skin research.
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Product information
CompoundAHK-Cu
Presentation100mg vial
CategoryCosmetic Research
AvailabilityIn stock
Batch COACertificate supplied with order
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For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
AHK-Cu (Alanyl-Histidyl-Lysine copper complex) is a biomimetic copper tripeptide designed for cosmetic and trichological research. Structurally related to the well-studied GHK-Cu, AHK-Cu was specifically optimised for research into hair follicle biology and dermal papilla cell function. The copper ion is chelated by the histidine and lysine residues, providing stability while remaining bioavailable for copper-dependent enzymatic processes. AHK-Cu has shown particular promise in in vitro studies examining dermal papilla cell proliferation and hair growth cycle signalling.
Mechanism of Action
AHK-Cu stimulates dermal papilla cell proliferation via activation of the Wnt/β-catenin signalling pathway, which is a master regulator of the hair follicle growth cycle (anagen induction). The copper ion serves as a cofactor for lysyl oxidase (essential for extracellular matrix cross-linking in the follicular niche) and superoxide dismutase (protecting rapidly dividing follicular cells from oxidative damage). AHK-Cu also upregulates VEGF expression in dermal papilla cells, promoting perifollicular angiogenesis that supports the metabolic demands of active hair growth.
Research Applications
- Hair follicle biology and anagen cycle research
- Dermal papilla cell signalling and proliferation studies
- Wnt/β-catenin pathway modulation in follicle models
- Copper-dependent enzyme activation research
- Scalp tissue remodelling and ECM studies
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Reconstitution calculator
Enter your reconstitution to get the draw volume for AHK-Cu.
Concentration50.00 mg/ml
Draw volume0.005 ml
On the syringe0.5 units
Doses per vial400
1units
Pull the plunger to 0.5 units on a 1 ml U‑100 syringe0.005 ml · 50.00 mg/ml · 400 doses per vial
Concentration = peptide mass ÷ water volume. Unit readings assume U-100 insulin syringes, graduated 100 units per millilitre. For laboratory calculation only — not dosing guidance.