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Cosmetic ResearchGHK-Cu
Copper-binding tripeptide studied for collagen synthesis, wound repair, and skin remodelling in dermatological research.
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Product information
CompoundGHK-Cu
Presentation50mg vial
CategoryCosmetic Research
AvailabilityIn stock
Batch COACertificate supplied with order
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For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide first identified in human plasma by Loren Pickart in 1973. Plasma levels of GHK-Cu decline with age, correlating with reduced regenerative capacity. It is one of the most extensively studied peptides in cosmetic and dermatological research, with over 100 published studies documenting its effects on collagen synthesis, anti-inflammatory pathways, and gene expression modulation. GHK-Cu has been shown to regulate the expression of over 4,000 human genes.
Mechanism of Action
GHK-Cu acts as a biological signal that reprograms cellular gene expression patterns. It stimulates collagen type I and III synthesis by dermal fibroblasts, upregulates decorin (a proteoglycan that regulates collagen fibre assembly), and suppresses excessive TGF-β signalling that leads to scarring. The copper ion serves as a cofactor for lysyl oxidase, the enzyme responsible for collagen and elastin cross-linking. Additionally, GHK-Cu attracts immune cells to injury sites via chemotactic signalling and promotes angiogenesis through VEGF and FGF-2 upregulation.
Research Applications
- Collagen synthesis and dermal remodelling studies
- Wound healing and tissue repair research
- Gene expression modulation and genomics research
- Anti-ageing mechanism investigation
- Antioxidant defence and SOD/GPx induction studies
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Reconstitution calculator
Enter your reconstitution to get the draw volume for GHK-Cu.
Concentration25.00 mg/ml
Draw volume0.010 ml
On the syringe1.0 units
Doses per vial200
1units
Pull the plunger to 1.0 units on a 1 ml U‑100 syringe0.010 ml · 25.00 mg/ml · 200 doses per vial
Concentration = peptide mass ÷ water volume. Unit readings assume U-100 insulin syringes, graduated 100 units per millilitre. For laboratory calculation only — not dosing guidance.