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Cosmetic ResearchMT1
Linear α-MSH analog with selective MC1R affinity, studied for melanogenesis and UV-protective pigmentation research.
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Product information
CompoundMT1
Presentation10mg vial
CategoryCosmetic Research
AvailabilityIn stock
Batch COACertificate supplied with order
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For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
Melanotan I (MT1), also known as afamelanotide, is a synthetic linear tridecapeptide analog of α-melanocyte-stimulating hormone (α-MSH). It has a [Nle4, D-Phe7] substitution that dramatically increases its potency and metabolic stability compared to native α-MSH. MT1 is more selective for the MC1R receptor than Melanotan II, making it a preferred research tool for studying melanogenesis without significant off-target melanocortin receptor effects. Under the brand name Scenesse, afamelanotide received EMA and FDA approval for erythropoietic protoporphyria (EPP).
Mechanism of Action
MT1 binds with high affinity and selectivity to MC1R on epidermal melanocytes. MC1R activation triggers the Gs-adenylate cyclase-cAMP-PKA cascade, leading to phosphorylation of CREB and upregulation of MITF (microphthalmia-associated transcription factor). MITF then transcriptionally activates the melanogenic enzymes tyrosinase, TRP-1, and TRP-2, driving the conversion of L-tyrosine through L-DOPA to eumelanin. The shift toward eumelanin (brown-black pigment) over pheomelanin (red-yellow, pro-oxidant) provides the photoprotective basis studied in UV-damage research.
Research Applications
- MC1R-selective melanogenesis research
- Eumelanin vs pheomelanin switching studies
- UV photoprotection and DNA damage prevention models
- Melanocyte biology and MITF transcription research
- Comparative melanocortin receptor selectivity studies
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Reconstitution calculator
Enter your reconstitution to get the draw volume for MT1.
Concentration5.00 mg/ml
Draw volume0.050 ml
On the syringe5.0 units
Doses per vial40
5units
Pull the plunger to 5.0 units on a 1 ml U‑100 syringe0.050 ml · 5.00 mg/ml · 40 doses per vial
Concentration = peptide mass ÷ water volume. Unit readings assume U-100 insulin syringes, graduated 100 units per millilitre. For laboratory calculation only — not dosing guidance.