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TB-5005mg · RESEARCH USE ONLY
TB-5005mg · RESEARCH USE ONLY
In stock COA DOCUMENT SLOT
Recovery ResearchTB-500
Synthetic fragment of Thymosin Beta-4, investigated in preclinical models for cell migration and tissue-repair signaling.
Research catalogueLaboratory-use positioning
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Product information
CompoundTB-500
Presentation5mg vial
CategoryRecovery Research
AvailabilityIn stock
Batch COACertificate supplied with order
€89.00
For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
TB-500 is a synthetic version of the naturally occurring 43-amino-acid peptide Thymosin Beta-4 (Tβ4), originally isolated from the thymus gland. Thymosin Beta-4 is one of the most abundant intracellular peptides and plays a central role in actin polymerisation. TB-500 reproduces the active region of Tβ4 responsible for cell migration and has been studied in preclinical contexts for its potential roles in tissue repair, anti-inflammation, and cardiac function.
Mechanism of Action
TB-500 acts primarily through sequestration of G-actin monomers, promoting actin polymerisation and cytoskeletal reorganisation essential for cell migration. It upregulates the expression of actin, which facilitates the movement of endothelial cells and keratinocytes to injury sites. Research also indicates anti-inflammatory activity through downregulation of pro-inflammatory cytokines and chemokines, alongside promotion of new blood vessel formation via VEGF-mediated pathways.
Research Applications
- Cell migration and tissue remodelling studies
- Cardiac tissue repair research in preclinical models
- Anti-inflammatory pathway investigation
- Wound healing and dermal repair research
- Actin cytoskeleton dynamics studies