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Growth ResearchGHRP-2
Synthetic hexapeptide growth hormone secretagogue studied for GH release, appetite regulation, and GHSR-1a signalling.
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Product information
CompoundGHRP-2
Presentation10mg vial
CategoryGrowth Research
AvailabilityIn stock
Batch COACertificate supplied with order
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For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
GHRP-2 (Growth Hormone Releasing Peptide-2, pralmorelin) is a synthetic hexapeptide GH secretagogue and one of the most potent compounds in the GHRP family. Developed in the 1990s by Bowers and Momany, it was instrumental in the discovery and characterisation of the ghrelin receptor (GHSR-1a) before the endogenous ligand ghrelin was identified. GHRP-2 remains a reference compound in growth hormone research, widely used for its robust and reproducible GH-releasing effects in both preclinical and clinical pharmacology studies.
Mechanism of Action
GHRP-2 activates GHSR-1a on pituitary somatotrophs through a Gq-coupled mechanism involving phospholipase C activation, IP3-mediated calcium release from intracellular stores, and calcium influx through L-type channels. This dual calcium signal triggers GH granule exocytosis. GHRP-2 also acts at the hypothalamic level to stimulate GHRH-releasing neurons and suppress somatostatin release, creating a dual amplification of GH secretion. Unlike ipamorelin, GHRP-2 has notable effects on cortisol, ACTH, and prolactin, reflecting broader activation of hypothalamic pathways including appetite-stimulating circuits.
Research Applications
- GH secretagogue receptor characterisation research
- Growth hormone dose-response and kinetics studies
- Hypothalamic GHRH-somatostatin axis investigation
- Appetite regulation and ghrelin pathway research
- Comparative GHS selectivity profiling
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Reconstitution calculator
Enter your reconstitution to get the draw volume for GHRP-2.
Concentration5.00 mg/ml
Draw volume0.050 ml
On the syringe5.0 units
Doses per vial40
5units
Pull the plunger to 5.0 units on a 1 ml U‑100 syringe0.050 ml · 5.00 mg/ml · 40 doses per vial
Concentration = peptide mass ÷ water volume. Unit readings assume U-100 insulin syringes, graduated 100 units per millilitre. For laboratory calculation only — not dosing guidance.