Low stock COA-25%
In stock COA DOCUMENT SLOT-25%
Growth ResearchKisspeptin
Neuropeptide studied for hypothalamic-pituitary-gonadal axis regulation and GnRH secretion control.
Research catalogueLaboratory-use positioning
Batch documentationBatch certificate supplied with order
Order trackingFrom payment to dispatch
Product information
CompoundKisspeptin
Presentation10mg vial
CategoryGrowth Research
AvailabilityIn stock
Batch COACertificate supplied with order
You save €16.00 on this presentation — an extra 10% off when you pay with crypto.
For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
Kisspeptin (metastin) is a family of neuropeptides encoded by the KISS1 gene, with kisspeptin-54 being the full-length form and shorter fragments (kisspeptin-14, -13, -10) retaining biological activity. Discovered initially as a metastasis suppressor, kisspeptin was subsequently identified as the endogenous ligand for the GPR54 receptor (now KISS1R), and its critical role in puberty onset and reproductive function has made it a cornerstone of neuroendocrine research. Loss-of-function mutations in KISS1R cause hypogonadotropic hypogonadism, demonstrating its essential role in reproductive axis activation.
Mechanism of Action
Kisspeptin binds to KISS1R (a Gq/11-coupled receptor) on GnRH neurons in the hypothalamic arcuate and anteroventral periventricular nuclei. Receptor activation triggers phospholipase C signalling, IP3-mediated calcium release, and PKC activation, leading to depolarisation and GnRH pulsatile secretion. GnRH in turn stimulates pituitary gonadotropins (LH and FSH). Kisspeptin neurons integrate metabolic signals (leptin, insulin), photoperiodic cues, and sex steroid feedback, functioning as the central gatekeeper of the HPG axis.
Research Applications
- Hypothalamic-pituitary-gonadal axis research
- GnRH neuron physiology and secretion studies
- Puberty onset and reproductive maturation models
- Metabolic-reproductive integration research
- Neuroendocrine feedback loop investigation
FREE TOOL
Reconstitution calculator
Enter your reconstitution to get the draw volume for Kisspeptin.
Concentration5.00 mg/ml
Draw volume0.050 ml
On the syringe5.0 units
Doses per vial40
5units
Pull the plunger to 5.0 units on a 1 ml U‑100 syringe0.050 ml · 5.00 mg/ml · 40 doses per vial
Concentration = peptide mass ÷ water volume. Unit readings assume U-100 insulin syringes, graduated 100 units per millilitre. For laboratory calculation only — not dosing guidance.