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Growth ResearchIpamorelin
Selective growth hormone secretagogue studied for GH release with minimal impact on cortisol and prolactin.
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Product information
CompoundIpamorelin
Presentation10mg vial
CategoryGrowth Research
AvailabilityIn stock
Batch COACertificate supplied with order
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For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
Ipamorelin is a synthetic pentapeptide growth hormone secretagogue (GHS) that acts as a selective agonist of the ghrelin/GHS receptor (GHSR-1a). Developed by Novo Nordisk, it stands out among GHS compounds for its high selectivity — it stimulates growth hormone release without significantly affecting cortisol, prolactin, or ACTH levels at effective GH-releasing doses. This selectivity profile makes it a valuable research tool for isolating GH-specific effects from broader hypothalamic-pituitary perturbations.
Mechanism of Action
Ipamorelin binds to GHSR-1a on pituitary somatotrophs, activating a Gq-phospholipase C-IP3-calcium signalling cascade that triggers GH granule exocytosis. Unlike GHRP-6 and GHRP-2, ipamorelin does not significantly activate the HPA axis at GH-releasing doses, suggesting receptor binding selectivity or differential activation of downstream effectors. It works synergistically with endogenous GHRH — co-administration amplifies GH pulse amplitude without disrupting the underlying pulsatile secretory pattern controlled by somatostatin withdrawal.
Research Applications
- Selective GH secretion research and dose-response studies
- Ghrelin receptor (GHSR-1a) pharmacology investigation
- GH axis specificity — cortisol/prolactin independence
- Synergistic GH-releasing mechanisms with GHRH analogs
- Somatotroph cell biology and signalling specificity
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Reconstitution calculator
Enter your reconstitution to get the draw volume for Ipamorelin.
Concentration5.00 mg/ml
Draw volume0.050 ml
On the syringe5.0 units
Doses per vial40
5units
Pull the plunger to 5.0 units on a 1 ml U‑100 syringe0.050 ml · 5.00 mg/ml · 40 doses per vial
Concentration = peptide mass ÷ water volume. Unit readings assume U-100 insulin syringes, graduated 100 units per millilitre. For laboratory calculation only — not dosing guidance.