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Semax10mg · RESEARCH USE ONLY
Semax10mg · RESEARCH USE ONLY
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Neuro ResearchSemax
Synthetic ACTH(4-10) analog with Pro-Gly-Pro tail, studied for neurotrophic factor expression and cognitive research.
Research catalogueLaboratory-use positioning
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Product information
CompoundSemax
Presentation10mg vial
CategoryNeuro Research
AvailabilityLow stock
Batch COACertificate supplied with order
€37.90
For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
Semax is a synthetic heptapeptide consisting of the ACTH(4-10) fragment (Met-Glu-His-Phe-Pro-Gly-Pro) — the portion of adrenocorticotropic hormone responsible for neurotrophic rather than steroidogenic activity. The C-terminal Pro-Gly-Pro extension protects against aminopeptidase degradation. Developed at the Institute of Molecular Genetics (Moscow), Semax is approved in Russia for cognitive and neurological applications and has accumulated extensive research documentation on neurotrophic factor regulation, neuroprotection, and cognitive enhancement in both animal and clinical models.
Mechanism of Action
Semax stimulates the expression of BDNF, NGF (nerve growth factor), and TrkB receptor in hippocampal and cortical neurons. It activates the MAPK/ERK signalling cascade downstream of tropomyosin kinase receptors, promoting neuronal survival, dendrite branching, and synaptic plasticity. Importantly, Semax lacks the adrenal steroidogenic effects of full-length ACTH — it does not stimulate cortisol production. It also modulates dopaminergic and serotonergic neurotransmission and has demonstrated antioxidant properties through regulation of genes involved in oxidative stress response.
Research Applications
- Neurotrophic factor (BDNF, NGF) expression research
- MAPK/ERK signalling in neuronal survival studies
- Cognitive function and synaptic plasticity models
- Neuroprotection and oxidative stress research
- ACTH fragment structure-activity relationship studies