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MOTS-C10mg · RESEARCH USE ONLY
MOTS-C10mg · RESEARCH USE ONLY
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Cellular ResearchMOTS-C
Mitochondrial-derived peptide studied for AMPK pathway activation, metabolic regulation, and exercise mimetic effects.
Research catalogueLaboratory-use positioning
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Product information
CompoundMOTS-C
Presentation10mg vial
CategoryCellular Research
AvailabilityIn stock
Batch COACertificate supplied with order
€39.90
For research use only. Not for human consumption, diagnostic, therapeutic or veterinary use.
Overview
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino-acid peptide encoded within the mitochondrial genome — specifically within the 12S rRNA gene. Discovered by Changhan David Lee at the University of Southern California in 2015, it was one of the first mitochondrial-derived peptides (MDPs) identified. MOTS-C is unique because it is encoded by mitochondrial DNA but acts on nuclear gene expression, representing a key retrograde signalling molecule from mitochondria to the nucleus.
Mechanism of Action
MOTS-C activates the AMPK (AMP-activated protein kinase) pathway by inhibiting the folate-methionine cycle in the de novo purine synthesis pathway, leading to accumulation of AICAR — an endogenous AMPK activator. Once activated, AMPK triggers a cascade that enhances glucose uptake, increases fatty acid oxidation, and promotes mitochondrial biogenesis. MOTS-C also translocates to the nucleus under metabolic stress, where it regulates adaptive nuclear gene expression through interaction with the antioxidant response element (ARE).
Research Applications
- AMPK pathway activation and metabolic signalling
- Exercise mimetic research and skeletal muscle biology
- Mitochondria-to-nucleus retrograde signalling studies
- Glucose homeostasis and insulin sensitivity models
- Ageing and mitochondrial-derived peptide research